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FINDeRS
FACTORS INFLUENCING NEUROLOGICAL DISEASE RISK & SEVERITY
Examining why some people with MS progress while others are stable
Ongoing work from the TONiC Study Group
OUR STUDIES
The Factors Influencing Neurological Disease Risk and Severity in Multiple Sclerosis (FINDeRS-MS) study has been born out of the Trajectories of Outcomes in Neurological Conditions (TONiC) study, which is an ongoing national study examining the factors that influence quality of life in patients with neurological conditions. It is one of the largest studies on quality of life in neurological conditions ever performed in the UK.
FINDeRS-MS is the next phase of the TONiC study
People wanting to join the FINDeRS-MS study should be a 'trilogy' TONiC participant, which means you must have completed and returned at least 3 questionnaire packs.
Click the TONiC study logo to learn more.
WHAT IS THE FINDeRS-MS STUDY INVESTIGATING?
THE RESEARCH QUESTION...
Why does MS affect some people much more than others over their lifetime?
THE STUDY IDEA...
We want to link clinical measures of disease severity in individuals with MS to their DNA and blood proteins to discover the genetic and biological factors that influence MS severity.
THE STUDY METHOD...
We will match the very detailed measures of disease severity recorded by the TONiC study to DNA and immune system proteins by inviting TONiC participants to donate a blood and urine sample. These samples will then be processed at Liverpool University (and will create a 'biobank') and then analysed by researchers at the universities of Liverpool, Cambridge and Nottingham, as well as with help from commercial companies involved in MS research.
FACTORS
MEASURED
Please click each of the shown underlined factors to learn more about them.
HOW WERE THESE FACTORS IDENTIFIED?
OUR NEWS
Click the below banners as they scroll to view the mentioned research update.
CURRENT INVESTIGATORS
OUR TEAM
 Prof. Carolyn YoungWalton Centre NHS Foundation Trust University of Liverpool |  Dr. Roger MillsWalton Centre NHS Foundation Trust University of Liverpool |
|---|---|
 Prof. Alan TennantLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds |  Prof. Stephen SawcerCambridge Neuroscience, University of Cambridge |
 Prof. Peter DiggleCHICAS, Lancaster Medical School, Lancaster University |  Prof. Dyfrig HughesCentre for Health Economics and Medicines Evaluation, Bangor University |
 Prof. Kate TillingMRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, Bristol University |  Rebecca TaylorCHICAS, Lancaster Medical School, Lancaster University |
 Richard ParkerMRC Integrative Epidemiology Unit, Bristol Medical School, Population Health Sciences, University of Bristol |  Prof. Joseph SlupskyDepartment of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool. |
 Prof. John QuinnDepartment of Pharmacology and Therapeutics Institute of Systems, Molecular & Integrative Biology, University of Liverpool |  Prof. Dawn LangdonProf. Dawn Langdon |
 Dr. Carrie ChadwickThe Neuroscience Laboratories, The Walton Centre NHS Foundation Trust |  Dr. Hikari AndoTONiC/FINDeRS study coordinator |
 People Living with MSPeople Living with MS |
INFORMATION
FOR
CLINICIANS
Learn more about FINDeRS-MS study eligibility criteria and the application of study outcomes
CONTACT THE
FINDeRS-MS STUDY
OUR ADDRESS
The Walton Centre NHS Foundation Trust
TONiC Team
Sid Watkins Building (S083)
Lower Lane, Fazakerley, Liverpool
L9 7BB
Tel: 0151 556 3693
